Columbia College of Nursing is located in a residential neighborhood near Lake Michigan and the University of Wisconsin-Milwaukee on the city's east side. The College is adjacent to Columbia-St. Mary's Columbia campus. It is served by most of the city's major bus routes.

An eclectic assortment of shops, restaurants, and recreational facilities is nearby. From the Columbia College of Nursing campus, students are close to many of Milwaukee's finest attractions. The College is less than one mile from the beaches of Lake Michigan, and close to the Milwaukee Art Museum. Parks, bike trails, a golf course and tennis courts are a short walk from campus. The internationally known Maier Festival Park, home of the famous Summerfest and ethnic festivals such as Festa Italiana and Irishfest, is a few short miles away.

The Columbia College of Nursing campus is located near many clinical sites, offering a convenient base for students as they enter the "hands-on" phase of their nursing education.

The Columbia College of Nursing facility offers students a comfortable and well-appointed base for their junior and senior years of study. It contains modern classrooms with interactive technology, faculty and administrative offices, plus meeting and study rooms.

The Helene Fuld Learning Resource Center contains both IBM and Macintosh computers, each with access to the Internet. The lab contains several color and laser printers and a document scanner for student use. CCON students are supplied a personal email address and network account their Junior year. Students can communicate with professors and each other through e-mail and many submit papers and assignments electronically.